Projects & publications
FFC#14/2023 “Novel therapeutic immunological targets from transcriptomic profiling of dendritic cells at the single-cell level and pathogenic Th17 cells interplay: perspective for next-generation immunotherapies in CF”
FFC#18/2020 “Counteracting inflammation triggered by P. aeruginosa-activated lung-infiltrating Th1/17 cells: a novel approach for precision medicine in CF”
GR-2017-0816 “Identification of molecular mechanisms leading to activation of pathogenic Th1/17 cells by pathobionts and gut microbiota in Crohn’s disease: a new target for therapeutic strategies”
PRIN 2022 “Identification and functional modulation of bacterial and human RNA-targets to prevent generation of pathogenic intestinal Th17 cells: perspective for a novel RNA-based therapy in Crohn’s disease.”
SEED 2019 “Dissecting the molecular mechanisms of Crohn’s disease pathogenesis using an intestinal 3D organoid model: a new tool towards a precision medicine strategy for CD”.
More recent Publications
AIEC-dependent pathogenic Th17 cell transdifferentiation in Crohn’s disease is suppressed by rfaP and ybaT deletion
An Intestinal Th17 Subset is Associated with Inflammation in Crohn’s Disease and Activated by Adherent-invasive Escherichia coli
Probiotic Lactobacillus and Bifidobacterium Strains Counteract Adherent-Invasive Escherichia coli (AIEC) Virulence and Hamper IL-23/Th17 Axis in Ulcerative Colitis, but Not in Crohn’s Disease